Kafka is a distributed system wherein data is stored across multiple nodes in the cluster. There is a high probability that one or more nodes in the cluster might fail. Fault tolerance means that the data is the system is protected and available even when some of the nodes in the cluster fail.
One of the ways in which Kafka provides fault tolerance is by making a copy of the partitions. The default replication factor is 3 which means for every partition in a topic, two copies are maintained. In case one of the broker fails, data can be fetched from its replica. This way Kafka can withstand N-1 failures, N being the replication factor.
Kafka also follows the leader-follower model. For every partition, one broker is elected as the leader while others are designated, followers. A leader is responsible for interacting with the producer/consumer. If the leader node goes down, then one of the remaining followers is elected as a leader.
Kafka also maintains a list of In Sync replicas. Say the replication factor is 3. That means there will be a leader partition and two follower partitions. However, the followers may not be in sync with the leader. The ISR shows the list of replicas that are in sync with the leader.